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Seminar of Interest (Nov 17): Dr. JingKe Weng
November 17, 2016 @ 11:00 am - 12:00 pm
Dr. Jing-Ke Weng from the Whitehead Institute of the Massachusetts Institute of Technology will be the guest speaker of the BMB Colloquium on November 17th at 11:00 AM. His seminar will be on the “Mechanistic Basis for Metabolic Evolution in Plants.”
Dr. Weng’s lab is interested in addressing five fundamental questions regarding the origin and evolution of chemodiversity in plants:
- What are the evolutionary trajectories through which multi-step specialized metabolic pathways and specific hormone-receptor pairs were assembled?
- What is the structural and mechanistic basis for the divergence or convergence of catalytic functions in evolving specialized enzymes?
- What roles do neutral mutation, catalytic promiscuity, protein dynamics, and stability play in natural evolution of new enzyme functions?
- Are there distinct biophysical constraints imposed on the same protein fold shaping the differential evolvability in primary and specialized metabolic enzymes?
- Can we uncover missing genetic and epigenetic components facilitating the rapid evolution of specialized metabolic systems in plants?
Biochemistry and Molecular Biology Colloquium Series